Compared with an SBP of 160.4 mm Hg (fourth), lower SBP levels of 114.1 mm Hg (first), 128.2 mm Hg (second), and 139.1 mm Hg (third) were associated with 1.9, 1.5, and 1.1 years gained in LE in people with T2D, respectively. Compared with a BMI of 41.4 (mean of the fourth quartile), lower BMIs of 24.3 (first), 28.6 (second), and 33.0 (third) were associated with 3.9, 2.9, and 2.0 additional life-years, respectively, in people with T2D.

Results Among 421 individuals, 194 (46%) were women, and the mean (SD) age was 65.6 (8.9) years. Main Outcomes and Measures Life expectancy. LE gains associated with achieving better control were estimated by moving people with T2D from the current quartile of each biomarker to the lower quartiles. Data were analyzed from January to October 2021.Įxposure The study population was grouped into quartiles on the basis of levels of HbA 1c, SBP, LDL-C, and BMI. The model was then used to conduct the simulation experiment on the study population over a lifetime. Objective To quantify potential gains in life expectancy (LE) among people with type 2 diabetes (T2D) associated with lowering glycated hemoglobin (HbA 1c), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and body mass index (BMI) toward optimal levels.ĭesign, Setting, and Participants In this decision analytical model, the Building, Relating, Assessing, and Validating Outcomes (BRAVO) diabetes microsimulation model was calibrated to a nationally representative sample of adults with T2D from the National Health and Nutrition Examination Survey (2015-2016) using their linked short-term mortality data from the National Death Index. The benefit of continually improving goal achievement has not been evaluated to date. Importance Improvements in control of factors associated with diabetes risk in the US have stalled and remain suboptimal. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.

Challenges in Clinical Electrocardiography.

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